Services
We offer
EIR Sciences offers contract research and epitope services within epitope identification, immunogenicity assessment, de-immunisation of proteins and immunogenicity optimisation. Our technologies are based on world leading methods within epitope predictions, which are public available and thus constantly assessed by the global scientific community. Read more about our technologies in the technology section. EIR Sciences has provided their services to several clients in Europe. The team and scientific advisors together have more than 60 years of experience within structural and immunological bioinformatics. Get an overview of our services here or read more below by expanding the sections
Epitope Identification
Not all parts of a protein are potential immunogenic. At EIR sciences we use cutting each immunological bioinformatics tools incorporated into EIR::predTM to identify the regions of a protein that have a high risk of evoking an immune responds in human or mammals.
Example of workflow
starting point
EIR Sciences receive one or more protein sequence for analyses. Experimental information if avaliable (for post filtrering of results).
The process
The EIR::pred™ technology applied usitize bioinformatic methods to identify regions (epitopes) in the protein that hold a high risk of evoking an immune reponse.
End results
A report that fully accounts for the findings, as well as interpret and analyse the results. Furthermore, an indepth description of the scientific background for the findings are included.
Immunogenicity Risk Assessment
The EIR::evalTM [Evaluate Immunogenicity Risk] technology provide relevant immunogenicity predictions which aid the decision process before, during and after clinical testing of novel or existing biopharmaceutical drugs.
Example of workflow
starting point
EIR Sciences receive one or more protein sequence for analyses. Experimental information if avaliable (for post filtrering of results).
The process
By applying EIR::eval™ technology EIR Sciences identify protein areas (epitopes) that potentially evokes an immune reponse in humans or animals and evaluate the immuniginicty risk profile. Evaluation will be performed on customer requriments and can for instance be based on ethnic cluster analyis or human genetic variation (see technology)
End results
A report that fully accounts for the findings, as well as interpret and analyse the results. Furthermore, an indepth description of the scientific background for the findings are included.
Deimmunization
The EIR::elimTM technology analyze the protein/antibody and finds potential immunogenic areas and suggest specific mutations for minimizing the protein immunogenicity risk profile.
Example of workflow
starting point
EIR Sciences receive one or more protein sequence for analyses. Experimental information if avaliable (for post filtrering of results).
The process
Using the EIR::elimTM technology EIR Sciences identify regions in the protein with immunogenicity risk and suggest relevant mutations for eliminating the risks aiming to decrease the protein immunogenicity risk profile
End results
A report that fully accounts for the findings, as well as interpret and analyse the results. Furthermore, an indepth description of the scientific background for the findings are included.
Immunogenicity Optimization
Using the epitope prediction technology implemented in the EIR::optiTM technology, the immunogenicity profile of a protein can be customized to meet the need of our costumers.
Example of workflow
starting point
EIR Sciences receive one or more protein sequence for analyses. Experimental information if avaliable (for post filtrering of results).
The process
Using the EIR::optiTM technology EIR Sciences identify mutations that increase the immuniginicity profile of a given protein. The technology identifies the least set of mutation needed to potentially induce an immune response in a specific or general population
End results
A report that fully accounts for the findings, as well as interpret and analyse the results. Furthermore, an indepth description of the scientific background for the findings are included.
Contract Research
The EIR sciences team together have more than 60 years of experience within structural and immunological bioinformatics and have participated in numerous intra-disciplinary public private partnership projects. EIR sciences have assisted a number of clients in development and execution of in-house immunology projects by providing the necessary knowhow in data-analysis. Core competences EIR sciences core competences are immunology bioinformatics including; protein pattern recognition, epitope discovery, structural immunology, sequence based virus and pathogen identification & classification